About Gene List

PF3D7_1207500

Genome location: Pf3D7_12_v3:347,896..349,423(+)

Genome classification: Core

Function and Localization

Product Description: RNA-binding protein, putative

SignalP Peptide: MKIQIIFILLLNMIHS

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0020011 apicoplast
Function GO:0003723 RNA binding

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring possibly expressed 0.02 0.99
Trophozoite expressed 0.19 0.87
Schizont expressed 0.11 0.91
Gametocyte expressed 0.13 0.92

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1207500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.176 | MFS: -3.255 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0606000)

  • Relative Growth Rate: 0.16 ± 0.09
  • Confidence: 6.31

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I5X0

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_146123

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 0 7 3 8
disruptive 0 7 8 13
missense 0 6 8 12

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 3 10 8 16
disruptive 1 14 18 40
missense 0 12 17 25

PlasmoDB Total SNPs: 33

Non-coding: 31 | Synonymous: 1 | Nonsynonymous: 1 | Stop Codon: 0

Protein Information

Protein Length: 182 | Molecular Weight (kDa): 21.539

UniProt ID(s): Q8I5X0

PDB ID(s): None

Isoelectric Point: 10.57

Protein Domain Annotations:

Source Family ID Description
InterPro IPR000504 RNA recognition motif domain
InterPro IPR035979 RNA-binding domain superfamily
PFam PF00076 RNA recognition motif domain
Superfamily SSF54928 RNA-binding domain superfamily

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
29435408 A putative RNA binding protein from Plasmodium vivax apicoplast. Garcia-Maurino SM, Diaz-Quintana A, ..., Diaz-Moreno I 10.1002/2211-5463.12351
30212465 Integrative proteomics and bioinformatic prediction enable a high-confidenceapicoplast proteome in malaria parasites. Boucher MJ, Ghosh S, ..., Yeh E 10.1371/journal.pbio.2005895