PF3D7_1207700

Genome location: Pf3D7_12_v3:351,850..354,006(-)

Genome classification: Core

Function and Localization

Product Description: 41-3 protein

SignalP Peptide: MLLRHNSFCICIILVLCSVQRCLS

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.03	0.99
Trophozoite	not expressed	0.04	0.98
Schizont	not expressed	0.02	0.99
Gametocyte	expressed	1.08	0.66

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1207700

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.141 | MFS: -2.858 | #Insertions: 0

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0606200)

Relative Growth Rate: 1.02 ± 0.12
Confidence: 5.70

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0606200)

Modification: Disrupted | RMgm-2077

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I0V6

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_134694

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	2	18	12	22
disruptive	0	22	15	47
missense	0	21	15	41

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	2	36	17	27
disruptive	5	41	29	68
missense	4	39	27	52

PlasmoDB Total SNPs: 76

Non-coding: 55 | Synonymous: 7 | Nonsynonymous: 13 | Stop Codon: 1

Protein Information

Protein Length: 375 | Molecular Weight (kDa): 43.426

UniProt ID(s): Q8I0V6, Q99019, Q9NHP4

PDB ID(s): None

Isoelectric Point: 5.08

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A