PF3D7_1207800

Genome location: Pf3D7_12_v3:354,195..357,606(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	expressed	0.09	0.96
Trophozoite	expressed	0.11	0.94
Schizont	expressed	0.02	0.98
Gametocyte	expressed	0.35	0.82

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1207800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: 0.267 | #Insertions: 14

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I5W9

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532977

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	11	55	30	59
disruptive	85	297	112	262
missense	44	215	88	216

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	23	95	39	67
disruptive	134	486	164	326
missense	67	376	127	245

PlasmoDB Total SNPs: 200

Non-coding: 18 | Synonymous: 106 | Nonsynonymous: 76 | Stop Codon: 0

Protein Information

Protein Length: 968 | Molecular Weight (kDa): 112.523

UniProt ID(s): Q8I5W9

PDB ID(s): None

Isoelectric Point: 4.1

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A

PMID	Title	Authors	DOI/Link
12368864	Genome sequence of the human malaria parasite Plasmodium falciparum.	Gardner MJ, Hall N, ..., Barrell B	10.1038/nature01097
16267556	A protein interaction network of the malaria parasite Plasmodium falciparum.	LaCount DJ, Vignali M, ..., Hughes RE	10.1038/nature04104