PF3D7_1207900

Genome location: Pf3D7_12_v3:357,855..359,377(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.06	0.97
Trophozoite	expressed	0.24	0.85
Schizont	not expressed	0.03	0.98
Gametocyte	possibly expressed	0.27	0.84

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1207900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.371 | MFS: -3.489 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A143ZZG4

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_107492

Most Similar Human Ortholog: F8VRG6

TM-align score: 0.58 | RMSD: 2.85

Seq Identity: 0.11 | Length: 56 / 394

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000171310	carbohydrate sulfotransferase 11

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	2	14	14	28
disruptive	7	53	33	72
missense	7	53	33	69

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	6	45	16	47
disruptive	12	137	40	107
missense	10	127	36	81

PlasmoDB Total SNPs: 66

Non-coding: 33 | Synonymous: 16 | Nonsynonymous: 17 | Stop Codon: 0

Protein Information

Protein Length: 394 | Molecular Weight (kDa): 47.792

UniProt ID(s): A0A143ZZG4

PDB ID(s): None

Isoelectric Point: 8.42

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A