PF3D7_1208100

Genome location: Pf3D7_12_v3:361,599..376,167(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 2

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0030686	90S preribosome
Component	GO:0005730	nucleolus
Component	GO:0032040	small-subunit processome

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	expressed	1.54	0.38
Trophozoite	possibly expressed	1.12	0.45
Schizont	not expressed	0.48	0.73
Gametocyte	not expressed	0.95	0.52

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1208100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.137 | MFS: -3.186 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: N/A

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532702

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	39	212	122	283
disruptive	113	568	341	835
missense	86	534	326	776

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	65	404	189	307
disruptive	219	1198	595	1092
missense	156	1056	544	892

PlasmoDB Total SNPs: 431

Non-coding: 83 | Synonymous: 218 | Nonsynonymous: 130 | Stop Codon: 0

Protein Information

Protein Length: 4469 | Molecular Weight (kDa): 533.648

UniProt ID(s): Q8I5W6

PDB ID(s): None

Isoelectric Point: 9.38

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A

PMID	Title	Authors	DOI/Link
12368864	Genome sequence of the human malaria parasite Plasmodium falciparum.	Gardner MJ, Hall N, ..., Barrell B	10.1038/nature01097
12368868	Sequence of Plasmodium falciparum chromosomes 2, 10, 11 and 14.	Gardner MJ, Shallom SJ, ..., Fraser CM	10.1038/nature01094