PF3D7_1208200 (CRMP3)

Genome location: Pf3D7_12_v3:376,552..387,483(+)

Genome classification: Core

Function and Localization

Product Description: cysteine repeat modular protein 3

SignalP Peptide: N/A

# Transmembrane Domains: 8

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0031362	anchored component of external side of plasma membrane
Process	GO:0030522	intracellular receptor signaling pathway
Process	GO:0046907	intracellular transport

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	possibly expressed	0.10	0.95
Trophozoite	not expressed	0.15	0.91
Schizont	not expressed	0.07	0.96
Gametocyte	not expressed	0.35	0.80

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1208200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -1.061 | #Insertions: 11

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Not different from wild type (Pb ortholog: PBANKA_0606700)

Modification: Disrupted | RMgm-584

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: N/A

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

Orthology to BindingDB Entries:

UniProt	Protein Name	Species	Homology Source	BindingDB Ligands
O00220	Tumor necrosis factor receptor superfamily member 10A	Homo sapiens	OrthoMCL BLAST	CHEMBL1253325CHEMBL2373027CHEMBL2373021

Orthology Information

Ortholog Group (OrthoMCL): OG6_134665

No human ortholog(s)

Protein Information

Protein Length: 3601 | Molecular Weight (kDa): 428.17

UniProt ID(s): A0A5K1K8N7

PDB ID(s): None

Isoelectric Point: 9.49

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR009030	Growth factor receptor cysteine-rich domain superfamily
InterPro	IPR011641	Tyrosine-protein kinase ephrin type A/B receptor-like
PFam	PF07699	Tyrosine-protein kinase ephrin type A/B receptor-like
Superfamily	SSF57184	Growth factor receptor cysteine-rich domain superfamily

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	17	170	109	229
disruptive	118	336	228	545
missense	89	312	212	479

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	43	331	166	256
disruptive	195	760	380	872
missense	135	648	333	657

PlasmoDB Total SNPs: 338

Non-coding: 20 | Synonymous: 180 | Nonsynonymous: 137 | Stop Codon: 1

PMID	Title	Authors	DOI/Link
12368864	Genome sequence of the human malaria parasite Plasmodium falciparum.	Gardner MJ, Hall N, ..., Barrell B	10.1038/nature01097
17253978	Plasmodium cysteine repeat modular proteins 1-4: complex proteins with rolesthroughout the malaria parasite life cycle.	Thompson J, Fernandez-Reyes D, ..., Waters AP	10.1111/j.1462-5822.2006.00885.x