Product Description: acyl carrier protein, mitochondrial
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005739 | mitochondrion |
| Function | GO:0000035 | acyl binding |
| Function | GO:0000036 | acyl carrier activity |
| Function | GO:0005515 | protein binding |
| Process | GO:0006633 | fatty acid biosynthetic process |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | possibly expressed | 0.05 | 0.97 |
| Trophozoite | expressed | 0.41 | 0.75 |
| Schizont | expressed | 0.05 | 0.96 |
| Gametocyte | expressed | 0.18 | 0.89 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1208300
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 0.122 | MFS: -3.08 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0606800)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I0V5
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 1 | 14 | 6 | 10 |
| disruptive | 0 | 18 | 6 | 24 |
| missense | 0 | 17 | 5 | 22 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 3 | 25 | 7 | 10 |
| disruptive | 3 | 39 | 19 | 52 |
| missense | 1 | 28 | 18 | 34 |
PlasmoDB Total SNPs: 108
Non-coding: 93 | Synonymous: 11 | Nonsynonymous: 4 | Stop Codon: 0
Protein Length: 157 | Molecular Weight (kDa): 18.452
UniProt ID(s): Q8I0V5
PDB ID(s): None
Isoelectric Point: 5.97
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR009081 | Phosphopantetheine binding ACP domain |
| InterPro | IPR036736 | ACP-like superfamily |
| PFam | PF14573 | Phosphopantetheine binding ACP domain |
| Superfamily | SSF47336 | ACP-like superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |
| 34612205 | Divergent acyl carrier protein decouples mitochondrial Fe-S cluster biogenesisfrom fatty acid synthesis in malaria parasites | Falekun S, Sepulveda J, ..., Sigala PA | 10.7554/eLife.71636 |