About Gene List

PF3D7_1208400

Genome location: Pf3D7_12_v3:390,219..395,814(+)

Genome classification: Core

Function and Localization

Product Description: amino acid transporter, putative

SignalP Peptide: N/A

# Transmembrane Domains: 10

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0016020 membrane
Process GO:0009410 response to xenobiotic stimulus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.04 0.98
Trophozoite possibly expressed 0.22 0.87
Schizont possibly expressed 0.28 0.82
Gametocyte possibly expressed 0.19 0.89

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1208400

Resistome Missense Mutations: Q608K, N1456I

Resistome Compounds with Missense Mutations: AN13762, BCH070

Resistome # Samples with Disruptive Mutations: 5 (2 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -1.474 | #Insertions: 6

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1446100)

  • Relative Growth Rate: 0.18 ± 0.16
  • Confidence: 5.05

RMgmDB ABS Phenotype: Not different from wild type (Pb ortholog: PY17X_0609400)

Modification: Disrupted | RMgm-4772

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I5W4

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_109770

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 8 48 28 107
disruptive 45 156 110 288
missense 27 141 97 255

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 16 122 66 121
disruptive 92 384 226 500
missense 50 331 189 357

PlasmoDB Total SNPs: 226

Non-coding: 73 | Synonymous: 105 | Nonsynonymous: 48 | Stop Codon: 0

Protein Information

Protein Length: 1564 | Molecular Weight (kDa): 185.931

UniProt ID(s): Q8I5W4

PDB ID(s): None

Isoelectric Point: 8.62

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
11152613 Predicting transmembrane protein topology with a hidden Markov model: applicationto complete genomes. Krogh A, Larsson B, von Heijne G, Sonnhammer EL 10.1006/jmbi.2000.4315
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
29326268 Mapping the malaria parasite druggable genome by using in vitro evolution andchemogenomics. Cowell AN, Istvan ES, ..., Winzeler EA 10.1126/science.aan4472