PF3D7_1208500

Genome location: Pf3D7_12_v3:395,960..401,562(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.06	0.97
Trophozoite	not expressed	0.21	0.88
Schizont	not expressed	0.04	0.97
Gametocyte	not expressed	0.35	0.80

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1208500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -2.203 | #Insertions: 3

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I5W3

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532544

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	22	70	52	124
disruptive	66	214	151	326
missense	60	190	129	284

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	32	158	74	156
disruptive	102	494	243	456
missense	81	413	211	346

PlasmoDB Total SNPs: 212

Non-coding: 38 | Synonymous: 101 | Nonsynonymous: 73 | Stop Codon: 0

Protein Information

Protein Length: 1753 | Molecular Weight (kDa): 208.674

UniProt ID(s): Q8I5W3

PDB ID(s): None

Isoelectric Point: 8.16

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR027417	P-loop containing nucleoside triphosphate hydrolase
PFam	N/A	N/A
Superfamily	SSF52540	P-loop containing nucleoside triphosphate hydrolase