Product Description: mitochondrial import inner membrane translocase subunit TIM10, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005744 | TIM23 mitochondrial import inner membrane translocase complex |
| Component | GO:0005743 | mitochondrial inner membrane |
| Component | GO:0005758 | mitochondrial intermembrane space |
| Component | GO:0005739 | mitochondrion |
| Function | GO:0015450 | protein-transporting ATPase activity |
| Process | GO:0045039 | protein insertion into mitochondrial inner membrane |
| Process | GO:0006626 | protein targeting to mitochondrion |
| Process | GO:0015031 | protein transport |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | expressed | 0.13 | 0.93 |
| Trophozoite | expressed | 0.34 | 0.80 |
| Schizont | expressed | 0.03 | 0.98 |
| Gametocyte | expressed | 0.28 | 0.84 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1208600
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 0.144 | MFS: -2.839 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0607100)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I5W2
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersOrthology to BindingDB Entries:
| UniProt | Protein Name | Species | Homology Source | BindingDB Ligands |
|---|---|---|---|---|
| P87108 | Mitochondrial import inner membrane translocase subunit TIM10 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | HOGENOM, OrthoDB, OrthoMCL | MLS000038396MLS000041934MLS000054763MLS000091924... |
Ortholog Group (OrthoMCL): OG6_103064
Most Similar Human Ortholog: P62072
TM-align score: 0.91 | RMSD: 1.41
Seq Identity: 0.36 | Length: 75 / 75
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000134809 | translocase of inner mitochondrial membrane 10 |
Protein Length: 75 | Molecular Weight (kDa): 8.537
UniProt ID(s): Q8I5W2
PDB ID(s): None
Isoelectric Point: 6.43
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR004217 | Tim10-like |
| InterPro | IPR027100 | Mitochondrial import inner membrane translocase subunit Tim10 |
| InterPro | IPR035427 | Tim10-like domain superfamily |
| PFam | PF02953 | Tim10-like |
| Superfamily | SSF144122 | Tim10-like domain superfamily |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
No passing variants found
PlasmoDB Total SNPs: 46
Non-coding: 45 | Synonymous: 1 | Nonsynonymous: 0 | Stop Codon: 0
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |
| 29925672 | Divergent Small Tim Homologues Are Associated with TbTim17 and Critical for theBiogenesis of TbTim17 Protein Complexes in Trypanosoma brucei | Smith JT Jr, Singha UK, Misra S, Chaudhuri M | 10.1128/mSphere.00204-18 |
| 34639127 | Cellular and Molecular Targets of Nucleotide-Tagged Trithiolato-Bridged AreneRuthenium Complexes in the Protozoan Parasites Toxoplasma gondii and Trypanosomabrucei | Anghel N, Muller J, ..., Hemphill A | 10.3390/ijms221910787 |