PF3D7_1208700

Genome location: Pf3D7_12_v3:403,291..404,918(+)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005739	mitochondrion

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	possibly expressed	0.10	0.95
Trophozoite	expressed	0.64	0.64
Schizont	expressed	0.08	0.95
Gametocyte	expressed	0.67	0.64

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1208700

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.139 | MFS: -2.799 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I5W1

"Best" AlphaFill ligand hit: PC (phosphocholine, Local RMSD=9.15) with 1WRA (Global RMSD=20.13)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_160742

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	5	17	12	28
disruptive	10	34	32	79
missense	10	34	30	73

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	8	41	24	27
disruptive	17	114	61	120
missense	12	98	50	80

PlasmoDB Total SNPs: 53

Non-coding: 29 | Synonymous: 17 | Nonsynonymous: 7 | Stop Codon: 0

Protein Information

Protein Length: 398 | Molecular Weight (kDa): 47.671

UniProt ID(s): Q8I5W1

PDB ID(s): None

Isoelectric Point: 9.69

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR027986	T-cell activation inhibitor, mitochondrial
InterPro	IPR028031	Domain of unknown function DUF4460
PFam	PF14687	Domain of unknown function DUF4460
Superfamily	N/A	N/A