PF3D7_1208800

Genome location: Pf3D7_12_v3:405,242..409,824(-)

Genome classification: Core

Function and Localization

Product Description: zinc finger protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 6

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0045121	membrane raft
Component	GO:0005886	plasma membrane
Function	GO:0017124	SH3 domain binding
Function	GO:0061630	ubiquitin protein ligase activity
Process	GO:0007165	signal transduction

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	expressed	1.26	0.47
Trophozoite	expressed	0.77	0.58
Schizont	expressed	0.57	0.67
Gametocyte	expressed	1.08	0.45

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1208800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -2.489 | #Insertions: 2

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I5W0

"Best" AlphaFill ligand hit: ANP (phosphoaminophosphonic acid-adenylate ester, Local RMSD=8.04) with 3LLT (Global RMSD=18.72)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532371

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	11	44	41	82
disruptive	76	153	82	226
missense	43	126	78	193

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	24	107	55	94
disruptive	113	340	187	375
missense	62	287	150	242

PlasmoDB Total SNPs: 223

Non-coding: 48 | Synonymous: 86 | Nonsynonymous: 89 | Stop Codon: 0

Protein Information

Protein Length: 1180 | Molecular Weight (kDa): 138.955

UniProt ID(s): Q8I5W0

PDB ID(s): None

Isoelectric Point: 6.54

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR001841	Zinc finger, RING-type
InterPro	IPR024162	Adaptor protein Cbl
PFam	PF13920	N/A
Superfamily	SSF57850	N/A