Product Description: protein phosphatase PPM11, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: 3.1.3.16 (Protein-serine/threonine phosphatase)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005634 | nucleus |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 0.28 | 0.86 |
| Trophozoite | expressed | 1.07 | 0.47 |
| Schizont | expressed | 1.09 | 0.47 |
| Gametocyte | expressed | 1.00 | 0.50 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1208900
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: -2.475 | #Insertions: 2
PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1207900)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I5V9
"Best" AlphaFill ligand hit: No AlphaFill hits
BRENDA EC Inhibitors:
| EC # | Name | EC Inhibitors |
|---|---|---|
| 3.1.3.16 | protein-serine/threonine phosphatase | ATPADPUDPAMPGTPUTPUMPNaFEDTAEGTAcAMPNADPH... |
No evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_100742
Most Similar Human Ortholog: Q8NI37
TM-align score: 0.81 | RMSD: 2.85
Seq Identity: 0.27 | Length: 276 / 1442
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000196850 | protein phosphatase targeting COQ7 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 8 | 84 | 42 | 89 |
| disruptive | 15 | 106 | 71 | 194 |
| missense | 11 | 93 | 65 | 174 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 19 | 168 | 56 | 83 |
| disruptive | 37 | 261 | 178 | 357 |
| missense | 27 | 215 | 144 | 239 |
PlasmoDB Total SNPs: 279
Non-coding: 196 | Synonymous: 51 | Nonsynonymous: 32 | Stop Codon: 0
Protein Length: 1442 | Molecular Weight (kDa): 166.864
UniProt ID(s): Q8I5V9
PDB ID(s): None
Isoelectric Point: 6.44
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001932 | PPM-type phosphatase domain |
| InterPro | IPR036457 | PPM-type phosphatase domain superfamily |
| InterPro | IPR039123 | Protein phosphatase 2C |
| PFam | N/A | N/A |
| Superfamily | SSF81606 | PPM-type phosphatase domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |