Product Description: mago-binding protein, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005737 | cytoplasm |
| Component | GO:0035145 | exon-exon junction complex |
| Component | GO:0034399 | nuclear periphery |
| Function | GO:0003723 | RNA binding |
| Process | GO:1903259 | exon-exon junction complex disassembly |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | expressed | 0.21 | 0.90 |
| Trophozoite | expressed | 0.46 | 0.72 |
| Schizont | possibly expressed | 0.09 | 0.94 |
| Gametocyte | possibly expressed | 0.21 | 0.88 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1209000
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.38 | MFS: -2.814 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I5V8
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_105546
Most Similar Human Ortholog: Q9BRP8
TM-align score: 0.33 | RMSD: 4.00
Seq Identity: 0.26 | Length: 76 / 167
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000170473 | PYM homolog 1, exon junction complex associated factor |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 4 | 7 | 11 |
| disruptive | 1 | 20 | 16 | 34 |
| missense | 1 | 18 | 15 | 28 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 1 | 11 | 10 | 13 |
| disruptive | 7 | 53 | 30 | 57 |
| missense | 4 | 44 | 27 | 34 |
PlasmoDB Total SNPs: 43
Non-coding: 35 | Synonymous: 4 | Nonsynonymous: 4 | Stop Codon: 0
Protein Length: 167 | Molecular Weight (kDa): 19.566
UniProt ID(s): Q8I5V8
PDB ID(s): None
Isoelectric Point: 10.35
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR015362 | WIBG, Mago-binding |
| InterPro | IPR036348 | WIBG, N-terminal domain superfamily |
| InterPro | IPR039333 | Partner of Y14 and mago |
| PFam | PF09282 | WIBG, Mago-binding |
| Superfamily | SSF101931 | WIBG, N-terminal domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |