Product Description: U6 snRNA-associated Sm-like protein LSm7, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:1990726 | Lsm1-7-Pat1 complex |
| Component | GO:0005689 | U12-type spliceosomal complex |
| Component | GO:0071004 | U2-type prespliceosome |
| Component | GO:0005688 | U6 snRNP |
| Component | GO:0071013 | catalytic step 2 spliceosome |
| Component | GO:0005634 | nucleus |
| Component | GO:1990904 | ribonucleoprotein complex |
| Component | GO:0005732 | sno(s)RNA-containing ribonucleoprotein complex |
| Component | GO:0005681 | spliceosomal complex |
| Component | GO:0097526 | spliceosomal tri-snRNP complex |
| Process | GO:0000375 | RNA splicing, via transesterification reactions |
| Process | GO:0000398 | mRNA splicing, via spliceosome |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 0.22 | 0.89 |
| Trophozoite | expressed | 0.32 | 0.80 |
| Schizont | expressed | 0.06 | 0.96 |
| Gametocyte | expressed | 0.18 | 0.89 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1209200
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 0.519 | MFS: -2.439 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I5V6
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_102418
Most Similar Human Ortholog: A0A087X2I5
TM-align score: 0.82 | RMSD: 1.09
Seq Identity: 0.50 | Length: 48 / 108
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000130332 | LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 8 | 6 | 13 |
| disruptive | 1 | 5 | 5 | 15 |
| missense | 1 | 5 | 4 | 14 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 18 | 7 | 10 |
| disruptive | 1 | 19 | 8 | 27 |
| missense | 1 | 17 | 7 | 22 |
PlasmoDB Total SNPs: 91
Non-coding: 88 | Synonymous: 1 | Nonsynonymous: 2 | Stop Codon: 0
Protein Length: 108 | Molecular Weight (kDa): 11.996
UniProt ID(s): Q8I5V6
PDB ID(s): None
Isoelectric Point: 5.86
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001163 | LSM domain, eukaryotic/archaea-type |
| InterPro | IPR010920 | LSM domain superfamily |
| InterPro | IPR017132 | Sm-like protein Lsm7 |
| PFam | PF01423 | LSM domain, eukaryotic/archaea-type |
| Superfamily | SSF50182 | LSM domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |