Product Description: telomere repeat-binding zinc finger protein
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0000781 | chromosome, telomeric region |
| Component | GO:0034399 | nuclear periphery |
| Component | GO:0005634 | nucleus |
| Function | GO:0080084 | 5S rDNA binding |
| Function | GO:0003677 | DNA binding |
| Function | GO:0003691 | double-stranded telomeric DNA binding |
| Function | GO:0018024 | histone-lysine N-methyltransferase activity |
| Process | GO:0034968 | histone lysine methylation |
| Process | GO:1904357 | negative regulation of telomere maintenance via telomere lengthening |
| Process | GO:0006355 | regulation of transcription, DNA-templated |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | not expressed | 0.23 | 0.89 |
| Trophozoite | possibly expressed | 0.87 | 0.54 |
| Schizont | expressed | 1.49 | 0.30 |
| Gametocyte | possibly expressed | 0.70 | 0.62 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1209300
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 3 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: -1.082 | #Insertions: 3
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0607700)
Modification: Mutated | RMgm-4317
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q7KQK4
"Best" AlphaFill ligand hit: MLT ((2r)-2-hydroxybutanedioic acid, Local RMSD=0.42) with 7YSF (Global RMSD=7.34)
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 35 | 65 | 37 | 96 |
| disruptive | 109 | 273 | 135 | 314 |
| missense | 65 | 202 | 100 | 235 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 46 | 130 | 48 | 97 |
| disruptive | 176 | 484 | 188 | 368 |
| missense | 102 | 340 | 150 | 256 |
PlasmoDB Total SNPs: 396
Non-coding: 51 | Synonymous: 165 | Nonsynonymous: 180 | Stop Codon: 0
Protein Length: 1461 | Molecular Weight (kDa): 170.853
PDB ID(s): None
Isoelectric Point: 9.02
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR013087 | Zinc finger C2H2-type |
| InterPro | IPR036236 | Zinc finger C2H2 superfamily |
| PFam | PF00096 | Zinc finger C2H2-type |
| Superfamily | SSF57667 | Zinc finger C2H2 superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 28288093 | Malaria parasites possess a telomere repeat-binding protein that shares ancestrywith transcription factor IIIA. | Bertschi NL, Toenhake CG, ..., Voss TS | 10.1038/nmicrobiol.2017.33 |
| 28851851 | Multifunctional Involvement of a C2 H2 Zinc Finger Protein (Pb Zfp) in Malaria Transmission, Histone Modification, and Susceptibility to D NA Damage Response | Gopalakrishnan AM, Aly ASI, Aravind L, Kumar N | 10.1128/mBio.01298-17 |