Product Description: ATP synthase mitochondrial F1 complex assembly factor 1, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005739 | mitochondrion |
| Process | GO:0033615 | mitochondrial proton-transporting ATP synthase complex assembly |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.01 | 1.00 |
| Trophozoite | expressed | 0.05 | 0.97 |
| Schizont | possibly expressed | 0.01 | 0.99 |
| Gametocyte | expressed | 0.05 | 0.96 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1209800
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.158 | MFS: -3.146 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I5V1
"Best" AlphaFill ligand hit: GST (geranyl s-thiolodiphosphate, Local RMSD=0.58) with 6VKZ (Global RMSD=18.91)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_102875
Most Similar Human Ortholog: I3L448
TM-align score: 0.90 | RMSD: 1.97
Seq Identity: 0.16 | Length: 187 / 189
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000123472 | ATP synthase mitochondrial F1 complex assembly factor 1 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 1 | 11 | 5 | 18 |
| disruptive | 1 | 17 | 5 | 24 |
| missense | 1 | 16 | 5 | 22 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 3 | 21 | 7 | 15 |
| disruptive | 2 | 35 | 14 | 53 |
| missense | 1 | 28 | 12 | 34 |
PlasmoDB Total SNPs: 0
Non-coding: 0 | Synonymous: 0 | Nonsynonymous: 0 | Stop Codon: 0
Protein Length: 189 | Molecular Weight (kDa): 23.124
UniProt ID(s): Q8I5V1
PDB ID(s): None
Isoelectric Point: 9.91
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR010591 | ATP11 |
| PFam | PF06644 | ATP11 |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 10744740 | ASC1/RAS2 suppresses the growth defect on glycerol caused by the atp1-2 mutationin the yeast Saccharomyces cerevisiae | Mabuchi T, Ichimura Y, Takeda M, Douglas MG | 10.1074/jbc.275.14.10492 |
| 12829692 | A purified subfragment of yeast Atp11p retains full molecular chaperone activity | Hinton A, Zuiderweg ER, Ackerman SH | 10.1074/jbc.M305353200 |
| 8617760 | Identification of functional domains in Atp11p. Protein required for assembly ofthe mitochondrial F1-ATPase in yeast | Wang ZG, Ackerman SH | 10.1074/jbc.271.9.4887 |
| 9878050 | Epistatic interactions of deletion mutants in the genes encoding the F1-ATPase inyeast Saccharomyces cerevisiae | Lai-Zhang J, Xiao Y, Mueller DM | 10.1093/emboj/18.1.58 |
| 10386611 | The Drosophila gene 2A5 complements the defect in mitochondrial F1-ATPaseassembly in yeast lacking the molecular chaperone Atp11p | Wang ZG, Schmid KJ, Ackerman SH | 10.1016/s0014-5793(99)00676-6 |
| 11096112 | Identification of a nuclear gene (FMC1) required for the assembly/stability ofyeast mitochondrial F(1)-ATPase in heat stress conditions | Lefebvre-Legendre L, Vaillier J, ..., di Rago JP | 10.1074/jbc.M009557200 |