Product Description: 50S ribosomal protein L1, apicoplast, putative
SignalP Peptide: N/A
# Transmembrane Domains: 1
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0020011 | apicoplast |
| Component | GO:0022625 | cytosolic large ribosomal subunit |
| Component | GO:0005739 | mitochondrion |
| Function | GO:0003723 | RNA binding |
| Function | GO:0003735 | structural constituent of ribosome |
| Process | GO:0000470 | maturation of LSU-rRNA |
| Process | GO:0006412 | translation |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.06 | 0.97 |
| Trophozoite | possibly expressed | 0.51 | 0.70 |
| Schizont | possibly expressed | 0.28 | 0.82 |
| Gametocyte | not expressed | 0.49 | 0.71 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1210000
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.191 | MFS: -3.282 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1221500)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I5U9
"Best" AlphaFill ligand hit: BU1 (1,4-butanediol, Local RMSD=0.51) with 2HW8 (Global RMSD=3.27)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_100942
Most Similar Human Ortholog: Q9BYD6
TM-align score: 0.60 | RMSD: 3.09
Seq Identity: 0.22 | Length: 220 / 339
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000169288 | mitochondrial ribosomal protein L1 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 3 | 16 | 14 | 16 |
| disruptive | 1 | 29 | 7 | 45 |
| missense | 1 | 29 | 7 | 40 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 6 | 34 | 14 | 19 |
| disruptive | 9 | 62 | 40 | 73 |
| missense | 6 | 47 | 36 | 57 |
PlasmoDB Total SNPs: 133
Non-coding: 119 | Synonymous: 9 | Nonsynonymous: 5 | Stop Codon: 0
Protein Length: 339 | Molecular Weight (kDa): 40.052
UniProt ID(s): Q8I5U9
PDB ID(s): None
Isoelectric Point: 10.45
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR023674 | Ribosomal protein L1-like |
| InterPro | IPR028364 | Ribosomal protein L1/ribosomal biogenesis protein |
| PFam | PF00687 | Ribosomal protein L1/ribosomal biogenesis protein |
| Superfamily | SSF56808 | Ribosomal protein L1-like |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 30212465 | Integrative proteomics and bioinformatic prediction enable a high-confidenceapicoplast proteome in malaria parasites. | Boucher MJ, Ghosh S, ..., Yeh E | 10.1371/journal.pbio.2005895 |
| 34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |
| 33311538 | Autoregulation of yeast ribosomal proteins discovered by efficient search forfeedback regulation | Roy B, Granas D, ..., Stormo GD | 10.1038/s42003-020-01494-z |
| 27180677 | DsRNA-mediated targeting of ribosomal transcripts RPS6 and RPL26 induces long-lasting and significant reductions in fecundity of the vector Aedes aegypti | Estep AS, Sanscrainte ND, Becnel JJ | 10.1016/j.jinsphys.2016.05.001 |
| 31439809 | The L1 stalk is required for efficient export of nascent large ribosomal subunitsin yeast | Musalgaonkar S, Black JJ, Johnson AW | 10.1261/rna.071811.119 |