About Gene List

PF3D7_1210100 (SYN2)

Genome location: Pf3D7_12_v3:454,764..457,276(-)

Genome classification: Core

Function and Localization

Product Description: syntaxin, Qa-SNARE family

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0031201 SNARE complex
Component GO:0012505 endomembrane system
Component GO:0005768 endosome
Component GO:0016021 integral component of membrane
Component GO:0005886 plasma membrane
Function GO:0005484 SNAP receptor activity
Function GO:0000149 SNARE binding
Process GO:0006887 exocytosis
Process GO:0006886 intracellular protein transport
Process GO:0048278 vesicle docking
Process GO:0006906 vesicle fusion

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite expressed N/A N/A
Ring possibly expressed 0.04 0.98
Trophozoite expressed 0.26 0.84
Schizont expressed 0.47 0.70
Gametocyte expressed 0.51 0.71

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1210100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.13 | MFS: -2.884 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I5U8

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_134698

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 0 0 0 0
disruptive 0 3 1 1
missense 0 0 0 0

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 0 0 0 0
disruptive 0 6 0 1
missense 0 0 0 0

PlasmoDB Total SNPs: 156

Non-coding: 148 | Synonymous: 6 | Nonsynonymous: 2 | Stop Codon: 0

Protein Information

Protein Length: 310 | Molecular Weight (kDa): 36.848

UniProt ID(s): Q0ZAE8, Q8I5U8

PDB ID(s): None

Isoelectric Point: 5.33

Protein Domain Annotations:

Source Family ID Description
InterPro IPR000727 Target SNARE coiled-coil homology domain
PFam N/A N/A
Superfamily SSF58038 N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
17240462 Identification of Plasmodium falciparum family of SNAREs. Ayong L, Pagnotti G, Tobon AB, Chakrabarti D https://pubmed.ncbi.nlm.nih.gov/17240462/
19103232 Plasmodium falciparum secretory pathway: characterization of PfStx1, a plasmamembrane Qa-SNARE. Parish LA, Rayner JC 10.1016/j.molbiopara.2008.11.011