PF3D7_1210200

Genome location: Pf3D7_12_v3:458,672..462,423(-)

Genome classification: Core

Function and Localization

Product Description: zinc finger protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	not expressed	0.03	0.99
Trophozoite	not expressed	0.02	0.99
Schizont	not expressed	0.05	0.97
Gametocyte	expressed	1.06	0.55

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1210200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -1.333 | #Insertions: 6

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0608600)

Modification: Disrupted | RMgm-2086

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I5U7

"Best" AlphaFill ligand hit: ATP (adenosine-5'-triphosphate, Local RMSD=1.02) with 6JWY (Global RMSD=26.51)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532497

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	21	56	27	76
disruptive	89	186	102	198
missense	56	147	77	157

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	38	97	57	70
disruptive	131	341	147	333
missense	83	263	113	215

PlasmoDB Total SNPs: 207

Non-coding: 64 | Synonymous: 65 | Nonsynonymous: 78 | Stop Codon: 0

Protein Information

Protein Length: 1000 | Molecular Weight (kDa): 118.38

UniProt ID(s): Q8I5U7

PDB ID(s): None

Isoelectric Point: 6.09

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR000571	Zinc finger, CCCH-type
InterPro	IPR036855	Zinc finger, CCCH-type superfamily
PFam	N/A	N/A
Superfamily	SSF90229	Zinc finger, CCCH-type superfamily