PF3D7_1210300

Genome location: Pf3D7_12_v3:465,011..466,098(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	possibly expressed	0.06	0.97
Trophozoite	expressed	0.11	0.93
Schizont	not expressed	0.01	0.99
Gametocyte	possibly expressed	0.14	0.91

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1210300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.126 | MFS: -2.902 | #Insertions: 0

PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_0608700)

Relative Growth Rate: 0.47 ± 0.17
Confidence: 4.90

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0608700)

Modification: Disrupted | RMgm-2087

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I5U6

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533393

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	1	8	6	13
disruptive	2	30	24	46
missense	2	29	22	40

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	1	23	7	8
disruptive	6	85	39	71
missense	6	76	34	36

PlasmoDB Total SNPs: 42

Non-coding: 30 | Synonymous: 7 | Nonsynonymous: 5 | Stop Codon: 0

Protein Information

Protein Length: 209 | Molecular Weight (kDa): 24.548

UniProt ID(s): Q8I5U6

PDB ID(s): None

Isoelectric Point: 5.32

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A