PF3D7_1210500

Genome location: Pf3D7_12_v3:470,028..471,828(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.16	0.92
Trophozoite	possibly expressed	0.12	0.93
Schizont	not expressed	0.02	0.99
Gametocyte	not expressed	0.15	0.91

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1210500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.277 | MFS: -3.309 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I5U4

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533161

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	4	17	10	24
disruptive	11	49	33	90
missense	11	48	31	79

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	7	37	15	20
disruptive	30	118	60	127
missense	21	100	54	88

PlasmoDB Total SNPs: 59

Non-coding: 36 | Synonymous: 12 | Nonsynonymous: 11 | Stop Codon: 0

Protein Information

Protein Length: 438 | Molecular Weight (kDa): 53.246

UniProt ID(s): Q8I5U4

PDB ID(s): None

Isoelectric Point: 10.44

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A