About Gene List

PF3D7_1210600

Genome location: Pf3D7_12_v3:471,059..475,975(-)

Genome classification: Core

Function and Localization

Product Description: kelch protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite expressed N/A N/A
Ring expressed 1.04 0.55
Trophozoite expressed 0.86 0.54
Schizont expressed 0.33 0.80
Gametocyte expressed 1.20 0.40

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1210600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.978 | MFS: -2.885 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I5U3

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532962

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 8 60 34 66
disruptive 29 119 86 218
missense 25 106 80 184

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 14 119 62 81
disruptive 59 312 129 322
missense 40 260 115 240

PlasmoDB Total SNPs: 178

Non-coding: 92 | Synonymous: 47 | Nonsynonymous: 39 | Stop Codon: 0

Protein Information

Protein Length: 1065 | Molecular Weight (kDa): 122.856

UniProt ID(s): Q8I5U3

PDB ID(s): None

Isoelectric Point: 6.31

Protein Domain Annotations:

Source Family ID Description
InterPro IPR011043 Galactose oxidase/kelch, beta-propeller
PFam N/A N/A
Superfamily SSF50965 Galactose oxidase/kelch, beta-propeller

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104