About Gene List

PF3D7_1211200

Genome location: Pf3D7_12_v3:491,674..497,464(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005737 cytoplasm
Component GO:0005634 nucleus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring possibly expressed 1.05 0.55
Trophozoite expressed 1.04 0.47
Schizont not expressed 0.48 0.73
Gametocyte not expressed 0.98 0.52

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1211200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.119 | MFS: -3.013 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0609700)

  • Relative Growth Rate: 0.09 ± 0.08
  • Confidence: 6.35

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0609700)

Modification: Tagged | RMgm-5249

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I5T8

"Best" AlphaFill ligand hit: GTX (s-hexylglutathione, Local RMSD=2.65) with 1Q4J (Global RMSD=39.71)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532345

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 19 84 48 119
disruptive 67 251 135 341
missense 43 214 122 300

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 29 162 75 130
disruptive 132 500 214 395
missense 77 414 193 303

PlasmoDB Total SNPs: 205

Non-coding: 24 | Synonymous: 114 | Nonsynonymous: 67 | Stop Codon: 0

Protein Information

Protein Length: 1831 | Molecular Weight (kDa): 219.648

UniProt ID(s): Q8I5T8

PDB ID(s): None

Isoelectric Point: 9.52

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
23181666 Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. Oehring SC, Woodcroft BJ, ..., Voss TS 10.1186/gb-2012-13-11-r108
36040030 TurboID Identification of Evolutionarily Divergent Components of the Nuclear PoreComplex in the Malaria Model Plasmodium berghei. Ambekar SV, Beck JR, Mair GR 10.1128/mbio.01815-22