Product Description: heat shock protein DNAJ homologue Pfj4
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0020036 | Maurer's cleft |
| Component | GO:0005737 | cytoplasm |
| Component | GO:0030430 | host cell cytoplasm |
| Component | GO:0005634 | nucleus |
| Function | GO:0030544 | Hsp70 protein binding |
| Function | GO:0051082 | unfolded protein binding |
| Process | GO:0009408 | response to heat |
| Process | GO:0006986 | response to unfolded protein |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 0.51 | 0.75 |
| Trophozoite | expressed | 0.70 | 0.61 |
| Schizont | expressed | 0.15 | 0.90 |
| Gametocyte | expressed | 0.63 | 0.65 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1211400
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.261 | MFS: -2.79 | #Insertions: 0
PlasmoGEM Phenotype: Insufficient data (Pb ortholog: PBANKA_0609900)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q7KQK3
"Best" AlphaFill ligand hit: 1PS (3-pyridinium-1-ylpropane-1-sulfonate, Local RMSD=2.30) with 5AYK (Global RMSD=9.14)
No associated EC numbersOrthology to BindingDB Entries:
| UniProt | Protein Name | Species | Homology Source | BindingDB Ligands |
|---|---|---|---|---|
| P31689 | DnaJ homolog subfamily A member 1 | Homo sapiens | OrthoDB | CHEMBL52073CHEMBL159171 |
Ortholog Group (OrthoMCL): OG6_102921
Most Similar Human Ortholog: C9JB42
TM-align score: 0.97 | RMSD: 0.48
Seq Identity: 0.65 | Length: 66 / 244
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000105993 | DnaJ heat shock protein family (Hsp40) member B6 |
| ENSG00000135924 | DnaJ heat shock protein family (Hsp40) member B2 |
Protein Length: 244 | Molecular Weight (kDa): 28.062
PDB ID(s): None
Isoelectric Point: 9.47
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001623 | DnaJ domain |
| InterPro | IPR018253 | DnaJ domain, conserved site |
| InterPro | IPR036869 | Chaperone J-domain superfamily |
| PFam | PF00226 | DnaJ domain |
| Superfamily | SSF46565 | Chaperone J-domain superfamily |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
No passing variants found
PlasmoDB Total SNPs: 201
Non-coding: 192 | Synonymous: 9 | Nonsynonymous: 0 | Stop Codon: 0
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 18674634 | The Plasmodium falciparum heat shock protein 40, Pfj4, associates with heat shockprotein 70 and shows similar heat induction and localisation patterns. | Pesce ER, Acharya P, ..., Blatch GL | 10.1016/j.biocel.2008.06.011 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 31631203 | A network-based approach reveals novel invasion and Maurer's clefts-relatedproteins in Plasmodium falciparum. | Das D, Krishnan SR, Roy A, Bulusu G | 10.1039/c9mo00124g |