About Gene List

PF3D7_1211500 (mtRPS18)

Genome location: Pf3D7_12_v3:507,320..509,574(-)

Genome classification: Core

Function and Localization

Product Description: ribosomal protein S18, mitochondrial

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005743 mitochondrial inner membrane
Component GO:0005763 mitochondrial small ribosomal subunit
Component GO:0005739 mitochondrion
Function GO:0070181 small ribosomal subunit rRNA binding
Function GO:0003735 structural constituent of ribosome
Process GO:0032543 mitochondrial translation

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.14 0.93
Trophozoite not expressed 0.30 0.82
Schizont not expressed 0.06 0.96
Gametocyte not expressed 0.38 0.77

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1211500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.386 | MFS: -3.224 | #Insertions: 1

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0610000)

  • Relative Growth Rate: 0.05 ± 0.04
  • Confidence: 7.73

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I5T6

"Best" AlphaFill ligand hit: GSH (glutathione, Local RMSD=3.58) with 6FZE (Global RMSD=26.22)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_101408

Most Similar Human Ortholog: D6RE70

TM-align score: 0.52 | RMSD: 2.90

Seq Identity: 0.04 | Length: 50 / 387

All Human Orthologs (OrthoMCL):

Gene ID Description
ENSG00000163319 mitochondrial ribosomal protein S18C

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 2 16 10 33
disruptive 4 33 16 66
missense 4 33 15 59

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 4 36 15 29
disruptive 17 73 44 82
missense 12 62 42 67

PlasmoDB Total SNPs: 63

Non-coding: 44 | Synonymous: 10 | Nonsynonymous: 9 | Stop Codon: 0

Protein Information

Protein Length: 387 | Molecular Weight (kDa): 47.172

UniProt ID(s): Q8I5T6

PDB ID(s): None

Isoelectric Point: 9.63

Protein Domain Annotations:

Source Family ID Description
InterPro IPR001648 Ribosomal protein S18
InterPro IPR036870 Ribosomal protein S18 superfamily
PFam PF01084 Ribosomal protein S18
Superfamily SSF46911 Ribosomal protein S18 superfamily

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
32273345 Genetic ablation of the mitoribosome in the malaria parasite Plasmodiumfalciparum sensitizes it to antimalarials that target mitochondrial functions. Ling L, Mulaka M, ..., Ke H 10.1074/jbc.RA120.012646
34494883 A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. van Esveld SL, Meerstein-Kessel L, ..., Huynen MA 10.1128/mSphere.00614-21