Genome location: Pf3D7_12_v3:507,320..509,574(-)
Genome classification: Core
Product Description: ribosomal protein S18, mitochondrial
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
Type | GO Term | Name |
---|---|---|
Component | GO:0005743 | mitochondrial inner membrane |
Component | GO:0005763 | mitochondrial small ribosomal subunit |
Component | GO:0005739 | mitochondrion |
Function | GO:0070181 | small ribosomal subunit rRNA binding |
Function | GO:0003735 | structural constituent of ribosome |
Process | GO:0032543 | mitochondrial translation |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
Stage | LR class | MCA mean | MCA prop. zeros |
---|---|---|---|
Sporozoite | not expressed | N/A | N/A |
Ring | not expressed | 0.14 | 0.93 |
Trophozoite | not expressed | 0.30 | 0.82 |
Schizont | not expressed | 0.06 | 0.96 |
Gametocyte | not expressed | 0.38 | 0.77 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1211500
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 0.386 | MFS: -3.224 | #Insertions: 1
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0610000)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I5T6
"Best" AlphaFill ligand hit: GSH (glutathione, Local RMSD=3.58) with 6FZE (Global RMSD=26.22)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101408
Most Similar Human Ortholog: D6RE70
TM-align score: 0.52 | RMSD: 2.90
Seq Identity: 0.04 | Length: 50 / 387
All Human Orthologs (OrthoMCL):
Gene ID | Description |
---|---|
ENSG00000163319 | mitochondrial ribosomal protein S18C |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
variant type | common | rare | doubleton | singleton |
---|---|---|---|---|
synonymous | 2 | 16 | 10 | 33 |
disruptive | 4 | 33 | 16 | 66 |
missense | 4 | 33 | 15 | 59 |
Any inclusion in genotype call
variant type | common | rare | doubleton | singleton |
---|---|---|---|---|
synonymous | 4 | 36 | 15 | 29 |
disruptive | 17 | 73 | 44 | 82 |
missense | 12 | 62 | 42 | 67 |
PlasmoDB Total SNPs: 63
Non-coding: 44 | Synonymous: 10 | Nonsynonymous: 9 | Stop Codon: 0
Protein Length: 387 | Molecular Weight (kDa): 47.172
UniProt ID(s): Q8I5T6
PDB ID(s): None
Isoelectric Point: 9.63
Protein Domain Annotations:
Source | Family ID | Description |
---|---|---|
InterPro | IPR001648 | Ribosomal protein S18 |
InterPro | IPR036870 | Ribosomal protein S18 superfamily |
PFam | PF01084 | Ribosomal protein S18 |
Superfamily | SSF46911 | Ribosomal protein S18 superfamily |
PMID | Title | Authors | DOI/Link |
---|---|---|---|
12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
32273345 | Genetic ablation of the mitoribosome in the malaria parasite Plasmodiumfalciparum sensitizes it to antimalarials that target mitochondrial functions. | Ling L, Mulaka M, ..., Ke H | 10.1074/jbc.RA120.012646 |
34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |