Product Description: lysine-specific histone demethylase 1, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: 1.14.11.27 ([Histone H3]-dimethyl-L-lysine(36) demethylase)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0034399 | nuclear periphery |
| Component | GO:0005634 | nucleus |
| Function | GO:0016491 | oxidoreductase activity |
| Function | GO:0046592 | polyamine oxidase activity |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.54 | 0.75 |
| Trophozoite | not expressed | 1.37 | 0.36 |
| Schizont | expressed | 0.47 | 0.74 |
| Gametocyte | not expressed | 1.06 | 0.47 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1211600
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: -1.364 | #Insertions: 13
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0610100)
Modification: Disrupted | RMgm-2095
More info: PhenoPlasm Link
AlphaFill Uniprot ID: N/A
"Best" AlphaFill ligand hit: No AlphaFill hits
BRENDA EC Inhibitors:
| EC # | Name | EC Inhibitors |
|---|---|---|
| 1.14.11.27 | [histone H3]-dimethyl-L-lysine36 demethylase | No BRENDA inhibitors |
No evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 31 | 130 | 89 | 189 |
| disruptive | 156 | 460 | 230 | 539 |
| missense | 95 | 378 | 194 | 448 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 55 | 248 | 140 | 194 |
| disruptive | 284 | 834 | 379 | 628 |
| missense | 158 | 668 | 333 | 482 |
PlasmoDB Total SNPs: 377
Non-coding: 55 | Synonymous: 147 | Nonsynonymous: 175 | Stop Codon: 0
Protein Length: 2961 | Molecular Weight (kDa): 350.587
UniProt ID(s): Q8I5T5
PDB ID(s): None
Isoelectric Point: 9.52
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001965 | Zinc finger, PHD-type |
| InterPro | IPR002937 | Amine oxidase |
| InterPro | IPR011011 | Zinc finger, FYVE/PHD-type |
| InterPro | IPR036188 | FAD/NAD(P)-binding domain superfamily |
| PFam | PF01593 | Amine oxidase |
| PFam | PF13450 | |
| Superfamily | SSF51905 | FAD/NAD(P)-binding domain superfamily |
| Superfamily | SSF54373 | Zinc finger, FYVE/PHD-type |
| Superfamily | SSF57903 |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 19765590 | Potential epigenetic regulatory proteins localise to distinct nuclearsub-compartments in Plasmodium falciparum. | Volz J, Carvalho TG, ..., Cowman AF | 10.1016/j.ijpara.2009.09.002 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |