Product Description: polyubiquitin
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0009986 | cell surface |
| Component | GO:0005737 | cytoplasm |
| Component | GO:0005634 | nucleus |
| Component | GO:0000151 | ubiquitin ligase complex |
| Function | GO:0031386 | protein tag |
| Function | GO:0031625 | ubiquitin protein ligase binding |
| Process | GO:0019941 | modification-dependent protein catabolic process |
| Process | GO:0000209 | protein polyubiquitination |
| Process | GO:0016567 | protein ubiquitination |
| Process | GO:0006511 | ubiquitin-dependent protein catabolic process |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 1.01 | 0.55 |
| Trophozoite | expressed | 1.78 | 0.25 |
| Schizont | expressed | 1.85 | 0.22 |
| Gametocyte | expressed | 1.33 | 0.40 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1211800
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.272 | MFS: -3.296 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0610300)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q7KQK2
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_100667
Most Similar Human Ortholog: F5GZ39
TM-align score: 0.98 | RMSD: 0.35
Seq Identity: 0.98 | Length: 61 / 381
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000150991 | ubiquitin C |
| ENSG00000170315 | ubiquitin B |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 1 | 1 | 3 |
| disruptive | 0 | 0 | 0 | 1 |
| missense | 0 | 0 | 0 | 1 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 3 | 1 | 3 | 2 |
| disruptive | 0 | 1 | 5 | 9 |
| missense | 0 | 0 | 1 | 3 |
PlasmoDB Total SNPs: 194
Non-coding: 132 | Synonymous: 61 | Nonsynonymous: 1 | Stop Codon: 0
Protein Length: 381 | Molecular Weight (kDa): 42.829
UniProt ID(s): Q26029, Q7KQK2, Q9U5M1
PDB ID(s): None
Isoelectric Point: 7.47
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR000626 | Ubiquitin-like domain |
| InterPro | IPR019954 | Ubiquitin conserved site |
| InterPro | IPR019956 | Ubiquitin domain |
| InterPro | IPR029071 | Ubiquitin-like domain superfamily |
| PFam | PF00240 | Ubiquitin-like domain |
| Superfamily | SSF54236 | Ubiquitin-like domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 28604779 | Lys48 ubiquitination during the intraerythrocytic cycle of the rodent malariaparasite, Plasmodium chabaudi. | Gonzalez-Lopez L, Carballar-Lejarazu R, ..., Hernandez-Hernandez FC | 10.1371/journal.pone.0176533 |
| 28759593 | Proteogenomic analysis of the total and surface-exposed proteomes of Plasmodiumvivax salivary gland sporozoites. | Swearingen KE, Lindner SE, ..., Mikolajczak SA | https://pubmed.ncbi.nlm.nih.gov/28759593/ |
| 10613704 | Intraerythrocytic polyubiquitin expression in Plasmodium falciparum is subjectedto developmental and heat-shock control | Horrocks P, Newbold CI | 10.1016/s0166-6851(99)00174-7 |