PF3D7_1212200

Genome location: Pf3D7_12_v3:539,788..543,197(-)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.12	0.94
Trophozoite	not expressed	0.29	0.83
Schizont	possibly expressed	0.05	0.97
Gametocyte	not expressed	0.58	0.68

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1212200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.131 | MFS: -3.156 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I5T0

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_139510

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	7	30	23	44
disruptive	22	95	68	152
missense	21	91	65	143

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	10	69	29	60
disruptive	41	237	104	221
missense	32	201	95	172

PlasmoDB Total SNPs: 144

Non-coding: 89 | Synonymous: 29 | Nonsynonymous: 25 | Stop Codon: 1

Protein Information

Protein Length: 735 | Molecular Weight (kDa): 88.662

UniProt ID(s): Q8I5T0

PDB ID(s): None

Isoelectric Point: 9.6

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A