About Gene List

PF3D7_1212400

Genome location: Pf3D7_12_v3:549,734..551,279(+)

Genome classification: Core

Function and Localization

Product Description: tetratricopeptide repeat protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring possibly expressed 0.05 0.97
Trophozoite possibly expressed 0.25 0.84
Schizont expressed 0.10 0.93
Gametocyte expressed 0.24 0.86

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1212400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.131 | MFS: -3.212 | #Insertions: 0

PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_1428400)

  • Relative Growth Rate: 0.23 ± 0.12
  • Confidence: 5.56

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1428400)

Modification: Disrupted | RMgm-3879

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I5S8

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_125373

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 3 16 9 18
disruptive 4 41 21 66
missense 4 40 20 59

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 4 33 16 28
disruptive 15 93 43 120
missense 11 84 36 79

PlasmoDB Total SNPs: 45

Non-coding: 35 | Synonymous: 6 | Nonsynonymous: 4 | Stop Codon: 0

Protein Information

Protein Length: 340 | Molecular Weight (kDa): 40.106

UniProt ID(s): Q8I5S8

PDB ID(s): None

Isoelectric Point: 9.47

Protein Domain Annotations:

Source Family ID Description
InterPro IPR011990 Tetratricopeptide-like helical domain superfamily
InterPro IPR019734 Tetratricopeptide repeat
PFam N/A N/A
Superfamily SSF48452 Tetratricopeptide-like helical domain superfamily

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
12368868 Sequence of Plasmodium falciparum chromosomes 2, 10, 11 and 14. Gardner MJ, Shallom SJ, ..., Fraser CM 10.1038/nature01094