PF3D7_1212600

Genome location: Pf3D7_12_v3:555,503..556,924(-)

Genome classification: Core

Function and Localization

Product Description: SND2 domain-containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 4

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0043231	intracellular membrane-bounded organelle
Process	GO:0006624	vacuolar protein processing

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	no data	N/A	N/A
Ring	no data	nd	nd
Trophozoite	no data	nd	nd
Schizont	no data	nd	nd
Gametocyte	no data	nd	nd

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1212600.2

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.144 | MFS: -2.953 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Not tested (Pb ortholog: PBANKA_1428600)

Modification: Other | RMgm-440

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C6S3K5

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_103372

Most Similar Human Ortholog: Q9BTX3

TM-align score: 0.67 | RMSD: 2.99

Seq Identity: 0.12 | Length: 131 / 151

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000168701	transmembrane protein 208

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	1	9	4	12
disruptive	0	9	11	28
missense	0	9	11	23

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	3	18	8	14
disruptive	0	43	27	52
missense	0	28	18	33

PlasmoDB Total SNPs: 95

Non-coding: 76 | Synonymous: 16 | Nonsynonymous: 3 | Stop Codon: 0

Protein Information

Protein Length: 151 | Molecular Weight (kDa): 18.11

UniProt ID(s): C6S3K5

PDB ID(s): None

Isoelectric Point: 9.84

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR008506	SRP-independent targeting protein 2/TMEM208
PFam	PF05620	SRP-independent targeting protein 2/TMEM208
Superfamily	N/A	N/A