Product Description: eukaryotic translation initiation factor 3 subunit A, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005852 | eukaryotic translation initiation factor 3 complex |
| Component | GO:0071540 | eukaryotic translation initiation factor 3 complex, eIF3e |
| Component | GO:0071541 | eukaryotic translation initiation factor 3 complex, eIF3m |
| Component | GO:0043614 | multi-eIF complex |
| Component | GO:0005634 | nucleus |
| Function | GO:0003729 | mRNA binding |
| Function | GO:0003743 | translation initiation factor activity |
| Process | GO:0001732 | formation of cytoplasmic translation initiation complex |
| Process | GO:0006446 | regulation of translational initiation |
| Process | GO:0002188 | translation reinitiation |
| Process | GO:0006413 | translational initiation |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 2.49 | 0.16 |
| Trophozoite | expressed | 2.25 | 0.13 |
| Schizont | expressed | 1.02 | 0.48 |
| Gametocyte | expressed | 1.14 | 0.46 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1212700
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.16 | MFS: -2.765 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I5S6
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_102668
Most Similar Human Ortholog: Q14152
TM-align score: 0.37 | RMSD: 5.19
Seq Identity: 0.27 | Length: 575 / 1377
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000107581 | eukaryotic translation initiation factor 3 subunit A |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 28 | 74 | 52 | 99 |
| disruptive | 44 | 123 | 70 | 208 |
| missense | 20 | 71 | 54 | 162 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 40 | 171 | 64 | 75 |
| disruptive | 70 | 249 | 154 | 287 |
| missense | 30 | 169 | 111 | 188 |
PlasmoDB Total SNPs: 289
Non-coding: 170 | Synonymous: 86 | Nonsynonymous: 33 | Stop Codon: 0
Protein Length: 1377 | Molecular Weight (kDa): 166.061
UniProt ID(s): Q8I5S6
PDB ID(s): None
Isoelectric Point: 6.78
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR000717 | Proteasome component (PCI) domain |
| InterPro | IPR027512 | Eukaryotic translation initiation factor 3 subunit A |
| PFam | PF01399 | Proteasome component (PCI) domain |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |
| 37730435 | Translational control by Trypanosoma brucei DRBD18 contributes to the maintenanceof the procyclic state | Ciganda M, Sotelo-Silveira J, ..., Read LK | 10.1261/rna.079625.123 |