Product Description: succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: 1.3.5.1 (Succinate dehydrogenase (quinone));1.3.99.1 (Deleted entry)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005739 | mitochondrion |
| Function | GO:0009055 | electron transfer activity |
| Function | GO:0008177 | succinate dehydrogenase (ubiquinone) activity |
| Function | GO:0000104 | succinate dehydrogenase activity |
| Process | GO:0009060 | aerobic respiration |
| Process | GO:0055114 | oxidation-reduction process |
| Process | GO:0022904 | respiratory electron transport chain |
| Process | GO:0006099 | tricarboxylic acid cycle |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 0.08 | 0.96 |
| Trophozoite | expressed | 0.34 | 0.78 |
| Schizont | expressed | 0.42 | 0.73 |
| Gametocyte | expressed | 0.55 | 0.68 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1212800
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 0.828 | MFS: -0.409 | #Insertions: 1
PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1428800)
RMgmDB ABS Phenotype: Not different from wild type (Pb ortholog: PBANKA_1428800)
Modification: Disrupted | RMgm-4609
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I5S5
"Best" AlphaFill ligand hit: UQ1 (ubiquinone-1, Local RMSD=0.08) with 1ZOY (Global RMSD=1.16)
BRENDA EC Inhibitors:
Orthology to BindingDB Entries:
| UniProt | Protein Name | Species | Homology Source | BindingDB Ligands |
|---|---|---|---|---|
| P21912 | Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial | HOGENOM, OMA, OrthoDB, OrthoMCL BLAST | CHEMBL4103147MLS000044645CHEMBL4097841CHEMBL4097841... | |
| O42772 | Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial | OMA | CHEMBL439507CHEMBL439507CHEMBL379116Antipiricullin... |
Ortholog Group (OrthoMCL): OG6_100664
Most Similar Human Ortholog: A0A087WXX8
TM-align score: 0.90 | RMSD: 2.05
Seq Identity: 0.60 | Length: 121 / 321
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000117118 | succinate dehydrogenase complex iron sulfur subunit B |
Protein Length: 321 | Molecular Weight (kDa): 37.752
PDB ID(s): None
Isoelectric Point: 9.25
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001041 | 2Fe-2S ferredoxin-type iron-sulfur binding domain |
| InterPro | IPR004489 | Succinate dehydrogenase/fumarate reductase iron-sulphur protein |
| InterPro | IPR006058 | 2Fe-2S ferredoxin, iron-sulphur binding site |
| InterPro | IPR009051 | Alpha-helical ferredoxin |
| InterPro | IPR017900 | 4Fe-4S ferredoxin, iron-sulphur binding, conserved site |
| InterPro | IPR025192 | Succinate dehydogenase/fumarate reductase N-terminal |
| InterPro | IPR036010 | 2Fe-2S ferredoxin-like superfamily |
| PFam | PF13085 | Succinate dehydogenase/fumarate reductase N-terminal |
| PFam | PF13534 | |
| Superfamily | SSF46548 | Alpha-helical ferredoxin |
| Superfamily | SSF54292 | 2Fe-2S ferredoxin-like superfamily |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
No passing variants found
PlasmoDB Total SNPs: 213
Non-coding: 199 | Synonymous: 11 | Nonsynonymous: 3 | Stop Codon: 0
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |