PF3D7_1212900 (BDP2)

Genome location: Pf3D7_12_v3:568,097..573,525(-)

Genome classification: Core

Function and Localization

Product Description: bromodomain protein 2, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005634	nucleus
Function	GO:0005515	protein binding

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	expressed	2.72	0.19
Trophozoite	expressed	1.75	0.25
Schizont	expressed	1.31	0.39
Gametocyte	not expressed	1.32	0.38

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1212900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.173 | MFS: -2.746 | #Insertions: 0

PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_1428900)

Relative Growth Rate: 0.65 ± 0.11
Confidence: 5.78

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1428900)

Modification: Disrupted | RMgm-3881

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I5S4

"Best" AlphaFill ligand hit: 15P (peg 1500, Local RMSD=0.17) with 4NRC (Global RMSD=0.88)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_127990

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	10	69	18	75
disruptive	30	103	70	168
missense	18	90	68	141

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	22	122	36	90
disruptive	48	270	176	328
missense	26	208	148	205

PlasmoDB Total SNPs: 189

Non-coding: 122 | Synonymous: 43 | Nonsynonymous: 24 | Stop Codon: 0

Protein Information

Protein Length: 1088 | Molecular Weight (kDa): 125.45

UniProt ID(s): Q8I5S4

PDB ID(s): None

Isoelectric Point: 9.63

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR001487	Bromodomain
InterPro	IPR018359	Bromodomain, conserved site
InterPro	IPR036427	Bromodomain-like superfamily
PFam	PF00439	Bromodomain
Superfamily	SSF47370	Bromodomain-like superfamily

Associated Publications

PMID	Title	Authors	DOI/Link
12368864	Genome sequence of the human malaria parasite Plasmodium falciparum.	Gardner MJ, Hall N, ..., Barrell B	10.1038/nature01097
16267556	A protein interaction network of the malaria parasite Plasmodium falciparum.	LaCount DJ, Vignali M, ..., Hughes RE	10.1038/nature04104
23181666	Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum.	Oehring SC, Woodcroft BJ, ..., Voss TS	10.1186/gb-2012-13-11-r108
26067602	A Plasmodium Falciparum Bromodomain Protein Regulates Invasion Gene Expression.	Josling GA, Petter M, ..., Duffy MF	10.1016/j.chom.2015.05.009
35493110	The Putative Bromodomain Protein PfBDP7 of the Human Malaria Parasite PlasmodiumFalciparum Cooperates With PfBDP1 in the Silencing of Variant Surface AntigenExpression.	Quinn JE, Jeninga MD, ..., Petter M	10.3389/fcell.2022.816558
31728527	Epigenetic reader complexes of the human malaria parasite, Plasmodium falciparum	Hoeijmakers WAM, Miao J, ..., Bartfai R	10.1093/nar/gkz1044