About Gene List

PF3D7_1213200 (MED18)

Genome location: Pf3D7_12_v3:577,198..578,445(+)

Genome classification: Core

Function and Localization

Product Description: mediator of RNA polymerase II transcription subunit 18, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0016592 mediator complex

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.05 0.97
Trophozoite possibly expressed 0.16 0.89
Schizont possibly expressed 0.03 0.98
Gametocyte possibly expressed 0.06 0.96

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1213200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -0.976 | #Insertions: 3

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I5S3

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_171396

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 3 5 13 17
disruptive 8 30 14 40
missense 8 30 14 38

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 3 23 9 20
disruptive 13 56 28 70
missense 12 55 27 52

PlasmoDB Total SNPs: 45

Non-coding: 29 | Synonymous: 6 | Nonsynonymous: 10 | Stop Codon: 0

Protein Information

Protein Length: 278 | Molecular Weight (kDa): 33.255

UniProt ID(s): Q8I5S3

PDB ID(s): None

Isoelectric Point: 7.03

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
35557691 Mediator Complex of the Malaria Parasite Plasmodium falciparum Associates withEvolutionarily Novel Subunits. Iyer UB, Park JE, ..., Featherstone M 10.1021/acsomega.2c00368