PF3D7_1213400

Genome location: Pf3D7_12_v3:579,595..581,325(-)

Genome classification: Core

Function and Localization

Product Description: kelch domain-containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	possibly expressed	0.01	1.00
Trophozoite	expressed	0.01	1.00
Schizont	expressed	0.02	0.99
Gametocyte	expressed	0.30	0.83

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1213400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.178 | MFS: -2.786 | #Insertions: 0

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1429200)

Relative Growth Rate: 1.03 ± 0.15
Confidence: 5.22

RMgmDB ABS Phenotype: Not different from wild type (Pb ortholog: PBANKA_1429200)

Modification: Disrupted | RMgm-5085

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I5S1

"Best" AlphaFill ligand hit: TAR (d(-)-tartaric acid, Local RMSD=8.18) with 6QZH (Global RMSD=13.28)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_170516

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	6	31	18	38
disruptive	6	18	17	63
missense	6	16	17	53

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	15	51	21	35
disruptive	12	61	34	79
missense	9	52	31	62

PlasmoDB Total SNPs: 22

Non-coding: 0 | Synonymous: 16 | Nonsynonymous: 6 | Stop Codon: 0

Protein Information

Protein Length: 576 | Molecular Weight (kDa): 66.006

UniProt ID(s): Q8I5S1

PDB ID(s): None

Isoelectric Point: 6.94

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR015915	Kelch-type beta propeller
PFam	N/A	N/A
Superfamily	SSF117281	Kelch-type beta propeller