About Gene List

PF3D7_1213500 (GPR180)

Genome location: Pf3D7_12_v3:583,089..585,323(+)

Genome classification: Core

Function and Localization

Product Description: integral membrane protein GPR180, putative

SignalP Peptide: MCKSHNYMFTFFLWIVLFFINEENIQG

# Transmembrane Domains: 7

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005886 plasma membrane
Process GO:0007186 G protein-coupled receptor signaling pathway

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.02 0.99
Trophozoite not expressed 0.01 1.00
Schizont possibly expressed 0.01 0.99
Gametocyte expressed 0.53 0.74

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1213500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.543 | MFS: -3.236 | #Insertions: 1

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1429300)

  • Relative Growth Rate: 0.93 ± 0.17
  • Confidence: 4.94

RMgmDB ABS Phenotype: Not different from wild type (Pb ortholog: PBANKA_1429300)

Modification: Mutated | RMgm-5198

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I5S0

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_109480

Most Similar Human Ortholog: Q86V85

TM-align score: 0.74 | RMSD: 3.87

Seq Identity: 0.18 | Length: 383 / 698

All Human Orthologs (OrthoMCL):

Gene ID Description
ENSG00000152749 G protein-coupled receptor 180

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 2 43 24 50
disruptive 14 55 26 84
missense 9 49 25 81

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 7 83 36 58
disruptive 28 128 58 159
missense 16 108 52 119

PlasmoDB Total SNPs: 75

Non-coding: 36 | Synonymous: 27 | Nonsynonymous: 12 | Stop Codon: 0

Protein Information

Protein Length: 698 | Molecular Weight (kDa): 83.62

UniProt ID(s): Q8I5S0

PDB ID(s): None

Isoelectric Point: 8.99

Protein Domain Annotations:

Source Family ID Description
InterPro IPR019336 Intimal thickness related receptor, IRP
PFam PF10192 Intimal thickness related receptor, IRP
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
11152613 Predicting transmembrane protein topology with a hidden Markov model: applicationto complete genomes. Krogh A, Larsson B, von Heijne G, Sonnhammer EL 10.1006/jmbi.2000.4315
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
35404079 A G-Protein-Coupled Receptor Modulates Gametogenesis via PKG-Mediated SignalingCascade in Plasmodium berghei. Wang PP, Jiang X, ..., Zhu X 10.1128/spectrum.00150-22