Product Description: dynein light chain 1, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005868 | cytoplasmic dynein complex |
| Component | GO:0030286 | dynein complex |
| Component | GO:0005875 | microtubule associated complex |
| Function | GO:0003774 | cytoskeletal motor activity |
| Function | GO:0045505 | dynein intermediate chain binding |
| Function | GO:0051959 | dynein light intermediate chain binding |
| Function | GO:0003777 | microtubule motor activity |
| Process | GO:0007018 | microtubule-based movement |
| Process | GO:2000582 | obsolete positive regulation of microtubule motor activity, plus-end-directed |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.01 | 0.99 |
| Trophozoite | expressed | 0.09 | 0.93 |
| Schizont | expressed | 0.02 | 0.98 |
| Gametocyte | expressed | 0.09 | 0.94 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1213600
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 0.929 | MFS: -2.263 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I5R9
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersOrthology to BindingDB Entries:
| UniProt | Protein Name | Species | Homology Source | BindingDB Ligands |
|---|---|---|---|---|
| Q96FJ2 | Dynein light chain 2, cytoplasmic | HOGENOM, OMA, OrthoDB, OrthoMCL BLAST | US11192893, Example 4US11192893, Example 5US11192893, Example 12US11192893, Example 27... |
Ortholog Group (OrthoMCL): OG6_101264
Most Similar Human Ortholog: P63167
TM-align score: 0.96 | RMSD: 1.43
Seq Identity: 0.78 | Length: 89 / 93
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000088986 | dynein light chain LC8-type 1 |
| ENSG00000264364 | dynein light chain LC8-type 2 |
Protein Length: 93 | Molecular Weight (kDa): 10.764
UniProt ID(s): Q8I5R9
PDB ID(s): 5WOF
Isoelectric Point: 7.87
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001372 | Dynein light chain, type 1/2 |
| InterPro | IPR019763 | Dynein light chain, type 1/2, conserved site |
| InterPro | IPR037177 | Dynein light chain superfamily |
| PFam | PF01221 | Dynein light chain, type 1/2 |
| Superfamily | SSF54648 | Dynein light chain superfamily |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
No passing variants found
PlasmoDB Total SNPs: 59
Non-coding: 56 | Synonymous: 3 | Nonsynonymous: 0 | Stop Codon: 0
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 23233536 | Dynein light chain 8a of Toxoplasma gondii, a unique conoid-localizedbeta-strand-swapped homodimer, is required for an efficient parasite growth | Qureshi BM, Hofmann NE, ..., Gupta N | 10.1096/fj.11-180992 |