Product Description: GPI ethanolamine phosphate transferase 3, putative
SignalP Peptide: N/A
# Transmembrane Domains: 16
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005783 | endoplasmic reticulum |
| Component | GO:0005789 | endoplasmic reticulum membrane |
| Function | GO:0051377 | mannose-ethanolamine phosphotransferase activity |
| Process | GO:0006506 | GPI anchor biosynthetic process |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | possibly expressed | N/A | N/A |
| Ring | not expressed | 0.17 | 0.92 |
| Trophozoite | expressed | 1.02 | 0.51 |
| Schizont | expressed | 0.59 | 0.68 |
| Gametocyte | expressed | 0.29 | 0.84 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1214100
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 1 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.135 | MFS: -2.876 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1429900)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I5R4
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_102855
Most Similar Human Ortholog: Q8TEQ8
TM-align score: 0.73 | RMSD: 4.17
Seq Identity: 0.18 | Length: 886 / 1373
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000165282 | phosphatidylinositol glycan anchor biosynthesis class O |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 8 | 58 | 49 | 108 |
| disruptive | 32 | 130 | 77 | 206 |
| missense | 24 | 121 | 69 | 179 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 14 | 130 | 61 | 121 |
| disruptive | 69 | 293 | 137 | 288 |
| missense | 41 | 256 | 119 | 223 |
PlasmoDB Total SNPs: 224
Non-coding: 129 | Synonymous: 47 | Nonsynonymous: 48 | Stop Codon: 0
Protein Length: 1373 | Molecular Weight (kDa): 164.63
UniProt ID(s): Q8I5R4
PDB ID(s): None
Isoelectric Point: 8.56
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR002591 | Type I phosphodiesterase/nucleotide pyrophosphatase/phosphate transferase |
| InterPro | IPR017850 | Alkaline-phosphatase-like, core domain superfamily |
| InterPro | IPR039524 | GPI ethanolamine phosphate transferase 3 |
| PFam | PF01663 | Type I phosphodiesterase/nucleotide pyrophosphatase/phosphate transferase |
| Superfamily | SSF53649 | Alkaline-phosphatase-like, core domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 11152613 | Predicting transmembrane protein topology with a hidden Markov model: applicationto complete genomes. | Krogh A, Larsson B, von Heijne G, Sonnhammer EL | 10.1006/jmbi.2000.4315 |
| 12117963 | Genes for glycosylphosphatidylinositol toxin biosynthesis in Plasmodiumfalciparum. | Delorenzi M, Sexton A, ..., Schofield L | 10.1128/IAI.70.8.4510-4522.2002 |
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |