Product Description: ER membrane protein complex subunit 6, putative
SignalP Peptide: N/A
# Transmembrane Domains: 2
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0072546 | EMC complex |
| Process | GO:0000045 | autophagosome assembly |
| Process | GO:0034975 | protein folding in endoplasmic reticulum |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | possibly expressed | N/A | N/A |
| Ring | expressed | 0.02 | 0.99 |
| Trophozoite | expressed | 0.04 | 0.98 |
| Schizont | expressed | 0.01 | 1.00 |
| Gametocyte | expressed | 0.03 | 0.98 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1214400
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 0.248 | MFS: -2.756 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I5R2
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_103722
Most Similar Human Ortholog: Q9BV81
TM-align score: 0.75 | RMSD: 2.22
Seq Identity: 0.26 | Length: 99 / 120
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000127774 | ER membrane protein complex subunit 6 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 1 | 0 | 0 |
| disruptive | 0 | 0 | 0 | 0 |
| missense | 0 | 0 | 0 | 0 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 1 | 0 | 0 |
| disruptive | 0 | 0 | 0 | 0 |
| missense | 0 | 0 | 0 | 0 |
PlasmoDB Total SNPs: 69
Non-coding: 61 | Synonymous: 4 | Nonsynonymous: 3 | Stop Codon: 1
Protein Length: 120 | Molecular Weight (kDa): 13.738
UniProt ID(s): Q8I5R2
PDB ID(s): None
Isoelectric Point: 9.64
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR008504 | ER membrane protein complex subunit 6 |
| InterPro | IPR029008 | Rab5-interacting protein family |
| PFam | PF07019 | Rab5-interacting protein family |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 36374934 | Reconstitution of an N-AChR from Brugia malayi, an evolved change inacetylcholine receptor accessory protein requirements in filarial parasites | Noonan JD, Beech RN | 10.1371/journal.ppat.1010962 |