About Gene List

PF3D7_1214500

Genome location: Pf3D7_12_v3:611,272..613,482(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring expressed 0.03 0.99
Trophozoite possibly expressed 0.05 0.97
Schizont expressed 0.01 1.00
Gametocyte expressed 0.75 0.66

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1214500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -1.522 | #Insertions: 2

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1430300)

  • Relative Growth Rate: 0.93 ± 0.13
  • Confidence: 5.49

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1430300)

Modification: Disrupted | RMgm-3887

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A144A024

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532980

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 4 12 0 13
disruptive 3 14 12 32
missense 3 14 11 31

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 5 22 6 15
disruptive 3 47 23 39
missense 3 40 22 33

PlasmoDB Total SNPs: 209

Non-coding: 180 | Synonymous: 23 | Nonsynonymous: 5 | Stop Codon: 1

Protein Information

Protein Length: 186 | Molecular Weight (kDa): 22.556

UniProt ID(s): A0A144A024

PDB ID(s): None

Isoelectric Point: 4.44

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104