Product Description: adrenodoxin-type ferredoxin, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005739 | mitochondrion |
| Function | GO:0009055 | electron transfer activity |
| Process | GO:0055114 | oxidation-reduction process |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | expressed | 0.10 | 0.95 |
| Trophozoite | expressed | 0.20 | 0.87 |
| Schizont | expressed | 0.02 | 0.99 |
| Gametocyte | expressed | 0.22 | 0.87 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1214600
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 0.303 | MFS: -2.46 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1430400)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I5R0
"Best" AlphaFill ligand hit: FAD (flavin-adenine dinucleotide, Local RMSD=0.02) with 1E6E (Global RMSD=1.33)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_100695
Most Similar Human Ortholog: Q6P4F2
TM-align score: 0.74 | RMSD: 2.27
Seq Identity: 0.47 | Length: 129 / 158
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000137714 | ferredoxin 1 |
| ENSG00000167807 | novel transcript |
| ENSG00000267673 | ferredoxin 2 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 1 | 7 | 11 | 7 |
| disruptive | 1 | 6 | 2 | 15 |
| missense | 1 | 6 | 1 | 12 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 22 | 9 | 13 |
| disruptive | 4 | 16 | 7 | 35 |
| missense | 3 | 12 | 6 | 25 |
PlasmoDB Total SNPs: 79
Non-coding: 72 | Synonymous: 6 | Nonsynonymous: 1 | Stop Codon: 0
Protein Length: 158 | Molecular Weight (kDa): 17.993
UniProt ID(s): Q8I5R0
PDB ID(s): None
Isoelectric Point: 5.2
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001041 | 2Fe-2S ferredoxin-type iron-sulfur binding domain |
| InterPro | IPR001055 | Adrenodoxin |
| InterPro | IPR036010 | 2Fe-2S ferredoxin-like superfamily |
| PFam | PF00111 | 2Fe-2S ferredoxin-type iron-sulfur binding domain |
| Superfamily | SSF54292 | 2Fe-2S ferredoxin-like superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |