PF3D7_1214800 (OBC13)

Genome location: Pf3D7_12_v3:616,536..617,998(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

More info:

• Malaria Parasite Metabolic Pathways (MPMP) Link
• BiGG Metabolic Model Link
• STRING Interaction Network Link

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1214800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 1 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.12 | MFS: -2.835 | #Insertions: 0

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1430600)

• Relative Growth Rate: 1.00 ± 0.16
• Confidence: 5.05

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1430600)

Modification: Disrupted | RMgm-3889

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I5Q8

"Best" AlphaFill ligand hit: No AlphaFill hits

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533522

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

No passing variants found

PlasmoDB Total SNPs: 124

Non-coding: 105 | Synonymous: 14 | Nonsynonymous: 4 | Stop Codon: 1

Protein Information

Protein Length: 109 | Molecular Weight (kDa): 13.13

UniProt ID(s): Q8I5Q8

PDB ID(s): None

Isoelectric Point: 10.25

Protein Domain Annotations: