About Gene List

PF3D7_1214900

Genome location: Pf3D7_12_v3:618,456..620,194(+)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 5

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0016020 membrane

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite expressed N/A N/A
Ring possibly expressed 0.00 1.00
Trophozoite expressed 0.03 0.98
Schizont expressed 0.04 0.97
Gametocyte expressed 0.04 0.97

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1214900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.754 | MFS: -2.246 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1430700)

  • Relative Growth Rate: 0.08 ± 0.05
  • Confidence: 7.22

RMgmDB ABS Phenotype: Not different from wild type (Pb ortholog: PBANKA_1430700)

Modification: Disrupted | RMgm-500

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I5Q7

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_121863

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 1 16 10 15
disruptive 2 4 7 24
missense 2 4 6 21

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 4 29 10 18
disruptive 3 27 30 53
missense 2 20 25 42

PlasmoDB Total SNPs: 63

Non-coding: 56 | Synonymous: 5 | Nonsynonymous: 2 | Stop Codon: 0

Protein Information

Protein Length: 245 | Molecular Weight (kDa): 27.379

UniProt ID(s): Q8I5Q7

PDB ID(s): None

Isoelectric Point: 4.51

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
11152613 Predicting transmembrane protein topology with a hidden Markov model: applicationto complete genomes. Krogh A, Larsson B, von Heijne G, Sonnhammer EL 10.1006/jmbi.2000.4315
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097