PF3D7_1215100

Genome location: Pf3D7_12_v3:622,520..626,579(+)

Genome classification: Core

Function and Localization

Product Description: SUN domain-containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005635	nuclear envelope
Function	GO:0043495	protein-membrane adaptor activity
Process	GO:0006998	nuclear envelope organization

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	expressed	0.34	0.85
Trophozoite	expressed	0.69	0.65
Schizont	expressed	0.10	0.94
Gametocyte	expressed	1.72	0.24

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1215100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.657 | MFS: -3.006 | #Insertions: 1

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1430900)

Relative Growth Rate: 0.91 ± 0.10
Confidence: 5.93

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1430900)

Modification: Disrupted | RMgm-3892

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I5Q5

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_139474

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	7	41	17	64
disruptive	29	98	47	149
missense	15	86	35	132

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	14	78	44	60
disruptive	54	214	123	264
missense	27	164	99	182

PlasmoDB Total SNPs: 197

Non-coding: 120 | Synonymous: 45 | Nonsynonymous: 32 | Stop Codon: 0

Protein Information

Protein Length: 953 | Molecular Weight (kDa): 113.033

UniProt ID(s): Q8I5Q5

PDB ID(s): None

Isoelectric Point: 8.37

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR012919	SUN domain
PFam	PF07738	SUN domain
Superfamily	N/A	N/A

PMID	Title	Authors	DOI/Link
12368864	Genome sequence of the human malaria parasite Plasmodium falciparum.	Gardner MJ, Hall N, ..., Barrell B	10.1038/nature01097
12368868	Sequence of Plasmodium falciparum chromosomes 2, 10, 11 and 14.	Gardner MJ, Shallom SJ, ..., Fraser CM	10.1038/nature01094