Product Description: peptidyl-prolyl cis-trans isomerase
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: 5.2.1.8 (Peptidylprolyl isomerase)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005737 | cytoplasm |
| Component | GO:0005739 | mitochondrion |
| Function | GO:0016018 | cyclosporin A binding |
| Function | GO:0003755 | peptidyl-prolyl cis-trans isomerase activity |
| Process | GO:0006457 | protein folding |
| Process | GO:0000413 | protein peptidyl-prolyl isomerization |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | not expressed | 0.02 | 0.99 |
| Trophozoite | expressed | 0.25 | 0.83 |
| Schizont | expressed | 0.09 | 0.93 |
| Gametocyte | expressed | 0.19 | 0.88 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1215200
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 0.992 | MFS: -2.201 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1431000)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I5Q4
"Best" AlphaFill ligand hit: LSA (saccharin, Local RMSD=0.05) with 4N1O (Global RMSD=1.95)
BRENDA EC Inhibitors:
| EC # | Name | EC Inhibitors |
|---|---|---|
| 5.2.1.8 | peptidylprolyl isomerase | ATPNEMSDSPCMBFK506QAEGPKAla-ProjugloneSer-ProGPI-1046RNase T1Rapamycin... |
No evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 17 | 10 | 14 |
| disruptive | 4 | 7 | 6 | 19 |
| missense | 4 | 6 | 6 | 19 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 5 | 34 | 11 | 19 |
| disruptive | 5 | 29 | 19 | 51 |
| missense | 4 | 25 | 17 | 38 |
PlasmoDB Total SNPs: 105
Non-coding: 95 | Synonymous: 8 | Nonsynonymous: 2 | Stop Codon: 0
Protein Length: 280 | Molecular Weight (kDa): 32.336
UniProt ID(s): Q8I5Q4
PDB ID(s): None
Isoelectric Point: 9.8
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR002130 | Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain |
| InterPro | IPR029000 | Cyclophilin-like domain superfamily |
| PFam | PF00160 | Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain |
| Superfamily | SSF50891 | Cyclophilin-like domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 9716503 | Detailed characterization of a cyclophilin from the human malaria parasitePlasmodium falciparum. | Berriman M, Fairlamb AH | 10.1042/bj3340437 |
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 21549842 | Overexpression, purification and assessment of cyclosporin binding of a family ofcyclophilins and cyclophilin-like proteins of the human malarial parasitePlasmodium falciparum. | Marin-Menendez A, Bell A | 10.1016/j.pep.2011.04.012 |
| 34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |