Product Description: 10 kDa chaperonin
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0020020 | food vacuole |
| Component | GO:0005759 | mitochondrial matrix |
| Component | GO:0005739 | mitochondrion |
| Function | GO:0051087 | chaperone binding |
| Function | GO:0046872 | metal ion binding |
| Function | GO:0051082 | unfolded protein binding |
| Process | GO:0051085 | chaperone cofactor-dependent protein refolding |
| Process | GO:0009408 | response to heat |
| Process | GO:0006986 | response to unfolded protein |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | expressed | 0.03 | 0.98 |
| Trophozoite | expressed | 0.13 | 0.92 |
| Schizont | expressed | 0.01 | 0.99 |
| Gametocyte | expressed | 0.12 | 0.93 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1215300
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 0.978 | MFS: -2.429 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1347800)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I5Q3
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersOrthology to BindingDB Entries:
| UniProt | Protein Name | Species | Homology Source | BindingDB Ligands |
|---|---|---|---|---|
| Q7BGE6 | Co-chaperonin GroES | OrthoMCL BLAST | CHEMBL4176281CHEMBL4160098CHEMBL4176281CHEMBL4168415... |
Ortholog Group (OrthoMCL): OG6_100490
Most Similar Human Ortholog: P61604
TM-align score: 0.90 | RMSD: 1.47
Seq Identity: 0.41 | Length: 102 / 103
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000115541 | heat shock protein family E (Hsp10) member 1 |
Protein Length: 103 | Molecular Weight (kDa): 11.15
PDB ID(s): None
Isoelectric Point: 5.14
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR011032 | GroES-like superfamily |
| InterPro | IPR018369 | Chaperonin GroES, conserved site |
| InterPro | IPR020818 | GroES chaperonin family |
| PFam | PF00166 | GroES chaperonin family |
| Superfamily | SSF50129 | GroES-like superfamily |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 0 | 1 | 0 |
| disruptive | 0 | 0 | 0 | 0 |
| missense | 0 | 0 | 0 | 0 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 0 | 1 | 0 |
| disruptive | 0 | 0 | 0 | 0 |
| missense | 0 | 0 | 0 | 0 |
PlasmoDB Total SNPs: 36
Non-coding: 32 | Synonymous: 3 | Nonsynonymous: 1 | Stop Codon: 0
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 15926202 | Organelle-specific cochaperonins in apicomplexan parasites. | Sato S, Wilson RJ | 10.1016/j.molbiopara.2005.01.010 |
| 21136929 | Food vacuole proteome of the malarial parasite Plasmodium falciparum. | Lamarque M, Tastet C, ..., Dubremetz JF | 10.1002/prca.200700112 |
| 34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |