PF3D7_1215400

Genome location: Pf3D7_12_v3:630,962..633,621(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	not expressed	0.08	0.96
Trophozoite	expressed	0.71	0.61
Schizont	expressed	0.80	0.58
Gametocyte	expressed	1.56	0.28

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1215400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.15 | MFS: -3.227 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I5Q2

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532818

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	4	24	22	27
disruptive	22	80	36	102
missense	16	72	35	86

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	8	50	22	40
disruptive	42	168	60	157
missense	30	139	54	116

PlasmoDB Total SNPs: 147

Non-coding: 70 | Synonymous: 51 | Nonsynonymous: 26 | Stop Codon: 0

Protein Information

Protein Length: 616 | Molecular Weight (kDa): 71.505

UniProt ID(s): Q8I5Q2

PDB ID(s): None

Isoelectric Point: 4.47

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A

PMID	Title	Authors	DOI/Link
12368864	Genome sequence of the human malaria parasite Plasmodium falciparum.	Gardner MJ, Hall N, ..., Barrell B	10.1038/nature01097
12368868	Sequence of Plasmodium falciparum chromosomes 2, 10, 11 and 14.	Gardner MJ, Shallom SJ, ..., Fraser CM	10.1038/nature01094