PF3D7_1215500

Genome location: Pf3D7_12_v3:633,892..634,545(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	no data	N/A	N/A
Ring	no data	0.00	1.00
Trophozoite	no data	0.00	1.00
Schizont	no data	0.00	1.00
Gametocyte	no data	0.32	0.85

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1215500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.331 | MFS: -3.321 | #Insertions: 0

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1431200)

Relative Growth Rate: 1.05 ± 0.19
Confidence: 4.72

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1431200)

Modification: Disrupted | RMgm-3895

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C6S3K6

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_107227

Most Similar Human Ortholog: Q7Z7H3

TM-align score: 0.57 | RMSD: 2.59

Seq Identity: 0.21 | Length: 57 / 69

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000158428	ciliogenesis associated TTC17 interacting protein

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	rare	doubleton	singleton
synonymous	4	0	2
disruptive	2	1	5
missense	2	1	5

Any inclusion in genotype call

variant type	rare	doubleton	singleton
synonymous	7	1	0
disruptive	10	8	13
missense	8	7	11

PlasmoDB Total SNPs: 25

Non-coding: 23 | Synonymous: 1 | Nonsynonymous: 1 | Stop Codon: 0

Protein Information

Protein Length: 69 | Molecular Weight (kDa): 8.25

UniProt ID(s): C6S3K6

PDB ID(s): None

Isoelectric Point: 4.42

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	SSF47391	N/A