About Gene List

PF3D7_1215600

Genome location: Pf3D7_12_v3:635,035..635,495(+)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005739 mitochondrion

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.06 0.97
Trophozoite not expressed 0.54 0.69
Schizont possibly expressed 0.57 0.66
Gametocyte expressed 1.00 0.49

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1215600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.127 | MFS: -3.223 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I5Q1

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_104552

Most Similar Human Ortholog: Q5VUM1

TM-align score: 0.18 | RMSD: 4.49

Seq Identity: 0.06 | Length: 35 / 140

All Human Orthologs (OrthoMCL):

Gene ID Description
ENSG00000154079 succinate dehydrogenase complex assembly factor 4

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 1 5 5 6
disruptive 2 17 11 38
missense 2 17 10 37

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 2 10 7 7
disruptive 8 36 26 36
missense 6 35 26 29

PlasmoDB Total SNPs: 17

Non-coding: 4 | Synonymous: 6 | Nonsynonymous: 7 | Stop Codon: 0

Protein Information

Protein Length: 140 | Molecular Weight (kDa): 17.025

UniProt ID(s): Q8I5Q1

PDB ID(s): None

Isoelectric Point: 8.87

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
34494883 A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. van Esveld SL, Meerstein-Kessel L, ..., Huynen MA 10.1128/mSphere.00614-21